Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
1p/19q-driven prognostic molecular classification for high-grade oligodendroglial tumors.
First author：Haihui Jiang
Corresponding author：Song Lin
essential_information
- Person in charge：Haihui Jiang
- Data Sources： OTHERS
- Number of papers：OTHERS20190283
- Published time：2014-08-24
2014-08-24
Published articles
Journal：J Neurooncol
Publication type: Clinical Study
IF(IF): 3.129
PMID: 25151507 Link To Pubmed Full text Download
Background And Purpose
Method
The present study was designed to project a molecular classification scheme based on the status of chromosome 1p and 19q. Patients (n = 117) with histological diagnosis of primary high-grade oligodendroglial tumors (HGOs) enrolled in the study. Fluorescence in situ hybridization (FISH) for chromosomes 1p and 19q was performed.
Conclusion
The classification scheme incorporating traditional pathology with molecular information can be served as a supplement of the current WHO classification system and contribute to the personalized treatment decision-making.
Main results
Univariate analysis showed that higher tumor grade, 1p/19q maintenance and 1q/19p co polysomy were confirmed as risk factors in HGOs (P < 0.01). Accordingly, patients with HGOs were divided into four subtypes which conferred remarkably distinct prognosis based on the number of risk factors (0 risk factor: HGOs-1, 1 risk factor: HGOs-2, 2 risk factors: HGOs-3, 3 risk factors: HGOs-4). Cox regression model revealed that the tumor grade was no longer independently associated with survival, while the molecular classification scheme showed a marked prognostic significance (HR = 0.359, 95 % CI 0.261-0.494, P < 0.001 for progression-free survival (PFS); HR = 0.393, 95 % CI 0.283-0.546, P < 0.001 for overall survival (OS)).