国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Hypoglossal-facial nerve 'side'-to-side neurorrhaphy using a predegenerated nerve autograft for facial palsy after removal of acoustic tumours at the cerebellopontine angle

第一作者：Liwei Zhang, Dezhi Li, Hong Wan

通讯作者：Song Liu

Based on fundamental concepts and our experimental

基本信息

2015-08-01

已发表文章

发表杂志：J Neurol Neurosurg Psychiatry

发表类型: Research Paper

影响因子(IF): 8.272

PMID: 25228445 Pubmed原文链接 全文下载

主要研究背景及目的

方法

To improve axonal regeneration, we used for the first time a predegenerated sural autograft for performing HN–FN ‘side’-to-side neurorrhaphy followed by postoperative facial exercise. We treated 12 patients who had experienced FN injury for 1–18 months as a result of acoustic tumour removal. All patients experienced facial grade V–VI paralysis according to the House-Brackmann scale, but their FN was anatomically preserved. No spontaneous facial reinnervation was detected before repair.

结论

Based on fundamental concepts and our experimental results, this new surgical method represents a major advance in the rehabilitation of FN injury.

主要结果

Although we did not perform fresh nerve grafts and HN–FN ‘side’-to-end neurorrhaphy as controls for ethical reasons, the reparative outcomes after nerve reconstruction were remarkable: functional improvements were detected as soon as 3 months after repair, House-Brackmann grade II or III FN functions were achieved in five and four patients, respectively, and there were no apparent signs of synkinesis. The three patients who experienced less satisfactory outcomes had exhibited facial palsy for more than 1 year accompanied by muscle atrophy, consistent with a need for rapid surgical intervention.