Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical characteristics and surgical outcomes of primary spinal paragangliomas
First author：Chenlong Yang
Corresponding author：Yulun Xu
essential_information
- Person in charge：Chenlong Yang
- Data Sources： OTHERS
- Number of papers：OTHERS20190320
- Published time：2015-02-27
2015-02-27
Published articles
Journal：Journal of Neuro-oncology
Publication type: Clinical Article
IF(IF): 4.13
PMID: 25720695 Link To Pubmed Full text Download
Background And Purpose
Method
We present the clinical data and long-term outcomes from a consecutive surgical series of 19 patients with pathologically diagnosed spinal paragangliomas. All of the patients had undergone surgical resection. Pre- and postoperative magnetic resonance imaging was performed and follow-up data and neurological functional assessment are presented and discussed. The mean age at diagnosis was 47.7 years, with a significant male predominance. The primary clinical symptoms were low back pain and sciatica. Magnetic resonance images (MRI) showed characteristic signs that help differentiate paragangliomas from other spinal tumors, including a "salt & pepper" sign, serpiginous flow void, and a peripheral hypointense rim. Also, a well-encapsulated appearance can be found intraoperatively. During a mean follow-up period of 62.1 months, remnant tumor progression was noted on MRI in three patients with incomplete resection.
Conclusion
Despite the benign course, gross total resection is ideal, given an increased risk of recurrence in situ. Timely recognition and surgical treatment should be emphasized to avoid progressive neurological deficits.
Main results
Pain symptoms were relieved immediately after surgical intervention, while motor and sphincter dysfunction were much slower to improve. Differential diagnosis of paraganglioma based on MR images alone is challenging, but the presence of specific characteristic features provides suggestive clues; however, accurate diagnosis depends on pathological criteria.