Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging
First author：Guihong Wang, Jingjuan Wang
Corresponding author：Tao Feng, Baoci Shan
essential_information
- Person in charge：Guihong Wang, Jingjuan Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190333
- Published time：2015-11-06
2015-11-06
Published articles
Journal：Journal of the Neurological Sciences
Publication type: Original Article
IF(IF): 3.181
PMID: 26671144 Link To Pubmed Full text Download
Background And Purpose
Method
In this study, we firstly modified the conventional VBM method to make it can process the T1-weighted FLAIR brain images. Then, we used this method on the 24 PSP patients and 23 healthy age- and sex-matched control subjects to find the local gray matter density changes of PSP patients.
Conclusion
We used the modified VBM technique into T1 FLAIR data to study the brain gray matter atrophy in PSP, and found some new atrophy areas, including pallidum, middle and posterior cingulum, lingual, fusiform gyrus and the post part of inferior temporal gyrus. These areas have not been described in the former VBM studies, but they revealed abnormity in the pathologic and other studies on PSP. Our results might be expected to provide significant underlining neurology information and diagnostic value for PSP.
Main results
Compared with healthy controls, GM reductions of PSP patients mainly located in the thalamus, basal ganglia, pons, midbrain, insular cortex, frontal cortex, temporal lobe, cerebellum, cingulate cortex and hippocampus.