国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Excessive Iron and -Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.

第一作者：ANG F

通讯作者：ZHANG WEI

Parkinson disease pure apathy iron a-synuclein

基本信息

  • 负责人：ANG F
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190413
  • 发表时间：2016-07-01

2016-07-01

已发表文章

发表杂志：Journal of Geriatric Psychiatry and Neurology

发表类型: Research Article

影响因子(IF): 2.68

PMID: 26940028 Pubmed原文链接 全文下载

主要研究背景及目的

方法

A total of 145 patients with PD without depression and dementia and 30 age-matched controls were consecutively recruited. Patients with PD were evaluated by Apathy Scale (AS), scales for motor symptoms and quality of life. The levels of iron, oxidative and neuroinflammatory factors, a-synuclein oligomer, and dopamine in cerebrospinal fluid (CSF) from patients with PD and controls were detected by enzyme-linked immunosorbent assay, chemical colorimetric method, and high-performance liquid chromatography. Comparisons between PD with pure apathy and with no pure apathy groups and correlation between AS score and the levels of above factors were analyzed.

结论

Patients with PD had high prevalence of pure apathy. Patients with PD having pure apathy had older age. Pure apathy reduced quality of life for patients without worsening motor function. Excessive iron and a-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress.

主要结果