国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma

第一作者：Sun, Li-Hua

通讯作者：Yang, Zheng-Xiang Jiang, Tao

PXN Glioma Oncogene Prognosis

基本信息

  • 负责人：Sun, Li-Hua
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190505
  • 发表时间：2017-01-01

2017-01-01

已发表文章

发表杂志：CNS Neurosci Ther

发表类型: Original Article

影响因子(IF): 5.243

PMID: 27637748 Pubmed原文链接 全文下载

主要研究背景及目的

方法

RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.

结论

PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy.

主要结果

In the discovery set, PXN overexpression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, P < 0.01). The results of the other validation datasets showed similar findings. PXN also served as an independent prognostic biomarker in glioblastoma patients. Functional assays showed that PXN contributed to glioma cell proliferation and invasion.