Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma
First author：Sun, Li-Hua
Corresponding author：Yang, Zheng-Xiang Jiang, Tao
essential_information
- Person in charge：Sun, Li-Hua
- Data Sources： OTHERS
- Number of papers：OTHERS20190505
- Published time：2017-01-01
2017-01-01
Published articles
Journal：CNS Neurosci Ther
Publication type: Original Article
IF(IF): 5.243
PMID: 27637748 Link To Pubmed Full text Download
Background And Purpose
Method
RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.
Conclusion
PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy.
Main results
In the discovery set, PXN overexpression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, P < 0.01). The results of the other validation datasets showed similar findings. PXN also served as an independent prognostic biomarker in glioblastoma patients. Functional assays showed that PXN contributed to glioma cell proliferation and invasion.