Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Evidence of dysexecutive syndrome in patients with acromegaly
First author：Shan, Shaobo
Corresponding author：Wan, Weiqing
essential_information
- Person in charge：Shan, Shaobo
- Data Sources： OTHERS
- Number of papers：OTHERS20190506
- Published time：2017-12-01
2017-12-01
Published articles
Journal：Pituitary
Publication type: Clinical Article
IF(IF): 4.107
PMID: 28823099 Link To Pubmed Full text Download
Background And Purpose
Method
We conducted five typical executive function tests (Stroop test, verbal fluency [VF] test, Hayling Sentence Completion Test [HSCT], N-back test, and Sustained Attention to Response Task [SART]) on 42 acromegalic patients and 42 strictly matched healthy controls. Comparative analyses were conducted for five major executive function domains. The Dysexecutive Questionnaire (DEX) was used to assess patients' subjective feelings about their executive function. All patients underwent a magnetic resonance imaging (MRI) examination and a blood test to determine their pituitary hormone levels before the tests were performed.
Conclusion
Acromegalic patients were severely impaired in semantic inhibition, executive processing, working memory and executive inhibition, and they have realized a portion of these deficits. A high level of IGF-1, disease duration may contribute to the impairment of specific aspects of executive function.
Main results
The patients exhibited worse results on the Stroop test, VF test, HSCT and N-back test compared to the healthy control group. Moreover, part B of the HSCT and the N-back test performance were negatively correlated with IGF-1 concentrations, and the duration of the disease was significantly associated with the Stroop color task results.