Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Transient Ischemic Attack in Pediatric Patients with Moyamoya Disease: Clinical Features, Natural History and Predictors of Stroke.
First author：Zhao, Meng
Corresponding author：Zhao, Jizong
essential_information
- Person in charge：Zhao, Meng
- Data Sources： OTHERS
- Number of papers：OTHERS20190524
- Published time：2017-10-01
2017-10-01
Published articles
Journal：Pediatr Neurol
Publication type: Original Article
IF(IF): 3.372
PMID: 28778481 Link To Pubmed Full text Download
Background And Purpose
Method
We reviewed 696 consecutive patients with moyamoya vasculopathy (155 pediatric patients and 541 adults) admitted to our hospital from 2009 to 2015 to identify pediatric patients with moyamoya with an initial presentation of TIA. We defined recurrent TIAs that involve more types of symptoms or symptom extensions as symptom progression. The risk factors for subsequent stroke were analyzed using time-to-event analyses.
Conclusion
Transient ischemic attacks have a relatively high recurrence rate in children with moyamoya and are associated with subsequent stroke. We identified the female sex, Suzuki grade greater than 3, and symptom progression as independent predictors of future strokes.
Main results
We identified 60 pediatric patients with moyamoya who had presented with TIA (initial presentation age, 10.0 ± 3.5 years). Motor weakness (n = 51 [85%]) was the most common initial presentation. During follow-up, 55 patients (91.7%) had recurrent TIAs and 14 (23.3%) had subsequent strokes. We identified female gender (hazard ratio, 5.08; 95% confidence interval, 1.40-18.47; P = 0.01), Suzuki grade greater than 3 (hazard ratio, 4.01; 95% confidence interval, 1.16-13.82; P = 0.03), and symptom progression (hazard ratio, 5.31; 95% confidence interval, 1.65-17.14; P = 0.01) as independent predictors of future stroke events.