Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Compare the safety and efficacy of endoscopic third ventriculostomy and ventriculoperitoneal shunt placement in infants and children with hydrocephalus: a systematic review and meta-analysis
First author：Li, Chuzhong
Corresponding author：Zhang, Yazhuo
essential_information
- Person in charge：Li, Chuzhong
- Data Sources： OTHERS
- Number of papers：OTHERS20190542
- Published time：2017-07-01
2017-07-01
Published articles
Journal：Int J Neurosci
Publication type: Clinical Study
IF(IF): 2.292
PMID: 28697664 Link To Pubmed Full text Download
Background And Purpose
Method
An extensive literature review regarding the clinical outcome, safety, and efficiency of ETV and shunting in treatment of hydrocephalus was conducted in Medline, PubMed, Cochrane, and Google Scholar databases up to November 27th, 2015. Patient demographics, ETV and shunting success and failure rates were extracted.
Conclusion
Both ETV and shunts are associated with similar 1 year success and failure rates. Therefore, there are no current indications to recommend one mode of treatment over the other. Future studies designed to assess the effectiveness of ETV and shunt procedures depending on patient's age and etiology are warranted.
Main results
A total of 7 two-arm studies were included for quantitative analysis and 25 single-arm studies were included for systematic review. The two-arm studies recruited a total of 6995 patients: 1046 in the ETV group and 5949 in the shunt group. The pooled results showed that the 1 year success rate of ETV and shunt-placement procedure were similar (pooled RR = 0.870, 95% CI = 0.680 to 1.112, P = 0.266). The failure rate in the ETV treatment group was 0.9 times higher than in the shunt group; however, the results did not reach statistical significance (pooled RR = 0.893, 95% CI = 0.576 to 1.383, P = 0.611).