Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas
First author：Zhai, Yixuan
Corresponding author：Zhang, Yazhuo
essential_information
- Person in charge：Zhai, Yixuan
- Data Sources： OTHERS
- Number of papers：OTHERS20190550
- Published time：2017-02-01
2017-02-01
Published articles
Journal：World Neurosurgery
Publication type: Research Article
IF(IF): 2.104
PMID: 27838423 Link To Pubmed Full text Download
Background And Purpose
Method
The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2-108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
Conclusion
In children and adolescents with clival chordomas, higher preoperative Karnofsky performance scale score, total resection, and lower levels of Ki-67 and CK8 expression are favorable prognostic factors. Platelet-derived growth factor receptor-β may play a role in tumorigenesis and epithelial-mesenchymal transition of clival chordomas.
Main results
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score <90 (P = 0.041) and patients in the nontotal resection group (P = 0.0497). Patients with lower Ki-67 expression levels had longer OS (P = 0.0207). Progression-free survival of patients with lower CK8 expression levels was significantly longer compared with patients with higher CK8 levels (P = 0.008). Expression levels of platelet-derived growth factor receptor-β were significantly correlated with expression levels of brachyury (P = 0.016).