国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas
第一作者：Zhai, Yixuan
通讯作者：Zhang, Yazhuo
基本信息
- 负责人：Zhai, Yixuan
- 数据来源： OTHERS
- 论文编号：OTHERS20190550
- 发表时间：2017-02-01
2017-02-01
已发表文章
主要研究背景及目的
方法
The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2-108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
结论
In children and adolescents with clival chordomas, higher preoperative Karnofsky performance scale score, total resection, and lower levels of Ki-67 and CK8 expression are favorable prognostic factors. Platelet-derived growth factor receptor-β may play a role in tumorigenesis and epithelial-mesenchymal transition of clival chordomas.
主要结果
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score <90 (P = 0.041) and patients in the nontotal resection group (P = 0.0497). Patients with lower Ki-67 expression levels had longer OS (P = 0.0207). Progression-free survival of patients with lower CK8 expression levels was significantly longer compared with patients with higher CK8 levels (P = 0.008). Expression levels of platelet-derived growth factor receptor-β were significantly correlated with expression levels of brachyury (P = 0.016).