Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Expression of Cathepsin K in Skull Base Chordoma
First author：Tian, Kaibing
Corresponding author：Zhang, Junting
essential_information
- Person in charge：Tian, Kaibing
- Data Sources： OTHERS
- Number of papers：OTHERS20190558
- Published time：2017-05-01
2017-05-01
Published articles
Journal：World Neurosurgery
Publication type: Research Article
IF(IF): 2.104
PMID: 28216213 Link To Pubmed Full text Download
Background And Purpose
Method
This study included 58 paraffin-embedded samples and 85 frozen samples of 94 patients. All clinical data corresponding to these patients were available. Immunohistochemical staining and quantitative real-time polymerase chain reaction were performed. Positive rate of immunohistochemical staining slices and delta cycle threshold value of quantitative real-time polymerase chain reaction represented the cathepsin K expression level in protein and gene level separately.
Conclusion
Increased cathepsin K expression in SBC was associated with tumor invasion and reduced PFS. The cathepsin K level in SBC also was associated with tumor stage, tumor lobulation, and septa.
Main results
In protein level, expression level (EL) of invasive tumors was increased compared with noninvasive tumors (P = 0.006), EL of tumors with dura erosion was increased compared with tumors without dura erosion (P = 0.001). Tumors with septa exhibited increased EL compared with tumors without septa (P = 0.001). Tumors with lobulation exhibited increased EL compared with tumors without lobulation (P = 0.000). Higher EL of cathepsin K was associated with reduced progression-free survival (PFS) (P = 0.015). In gene level, tumors with septa showed higher EL than tumors without septa (P = 0.015), and tumors with lobulation showed higher EL than tumors without lobulation (P = 0.049). Cathepsin K EL was an independent risk factor for reduced PFS, and an increased level of cathepsin K in SBC was associated with reduced PFS (P = 0.042).