Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Ischemic Stroke in Young Adults with Moyamoya Disease: Prognostic Factors for Stroke Recurrence and Functional Outcome after Revascularization.
First author：Zhao, Meng
Corresponding author：Zhao, Jizong
essential_information
- Person in charge：Zhao, Meng
- Data Sources： OTHERS
- Number of papers：OTHERS20190566
- Published time：2017-07-01
2017-07-01
Published articles
Journal：World Neurosurg
Publication type: Original Article
IF(IF): 2.104
PMID: 28408257 Link To Pubmed Full text Download
Background And Purpose
Method
We reviewed 696 consecutive patients with moyamoya disease admitted to our hospital from 2009-2015 and identified patients aged 18-45 years with first-ever stroke. Follow-up was conducted via face-to-face or structured telephone interviews. Outcome measures were recurrent stroke events and unfavorable functional outcomes (modified Rankin Scale >2).
Conclusion
We identified diabetes as an independent risk factor for recurrent strokes and unfavorable functional outcomes after revascularization in young stroke patients with moyamoya disease.
Main results
We included 121 young patients with moyamoya disease suffering from stroke (initial presentation age, 35.4 ± 7.5 years). All patients underwent revascularization after the acute phase of initial stroke events as the secondary prevention for recurrences. During follow-up (median, 40 months), 9 patients (7.4%) experienced recurrent strokes and 8 of them (6.6%) suffered unfavorable functional outcomes. In the multivariate analysis, diabetes was an independent predictor for stroke recurrences (hazard ratio 6.76; 95% confidence interval 1.30-35.11; P = 0.02) and was significantly associated with unfavorable functional outcomes (odds ratio 7.87; 95% confidence interval 1.42-38.74; P = 0.01).