国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Comparison of Stroke Prediction Accuracy of ABCD2 and ABCD3-I in Patients with Transient Ischemic Attack: A Meta-Analysis
第一作者：Zhao, Meng
通讯作者：Zhao, Jizong
基本信息
- 负责人：Zhao, Meng
- 数据来源： OTHERS
- 论文编号：OTHERS20190586
- 发表时间：2017-10-01
2017-10-01
已发表文章
发表杂志：Journal of Stroke & Cerebrovascular Diseases
发表类型: Meta Analysis
影响因子(IF): 2.136
PMID: 28647418 Pubmed原文链接 全文下载
主要研究背景及目的
方法
Medline, PubMed, Embase, and manuscript references were searched to identify studies that directly compared the stroke predictive powers of ABCD2 and ABCD3-I scores. We conducted a diagnostic meta-analysis using bivariate random effects models, and the predictive powers of ABCD2 and ABCD3-I scores were assessed by their summary sensitivity and specificity. Then, we applied the results to a hypothetical cohort of 1000 patients with TIA to calculate the effect per 1000 patients triaged for stroke prevention in a virtual setting.
结论
ABCD3-I scores had a better sensitivity but poorer specificity than ABCD2 scores. However, in community-based referring settings, it is more suitable to use ABCD2 at initial triage and deciding on urgency of specialist assessment. The prognostic utility of each of the components of the scores should be carefully considered rather than dichotomized scores during clinical triage.
主要结果
Of the 35 identified studies on ABCD2 and ABCD3-I, 6 studies (7364 participants) directly compared the diagnostic accuracies of ABCD2 and ABCD3-I scores for occurrence of a future stroke. The pooled sensitivities of ABCD2 versus ABCD3-I were 79.9% (62.2%-90.6%) versus 96.1% (90.2%-98.5%) at 7 days (P = .022), and 76.6% (63.8%-85.8%) versus 94.6% (88.9%-97.5%) at 90 days (P = .001). The pooled specificities of ABCD2 versus ABCD3-I were 29.2% (18.2%-43.3%) versus 17.7% (8.5%-33.3%) at 7 days (P = .214), and 40.3% (25.0%-57.7%) versus 20.2% (12.6%-30.6%) at 90 days (P = .032).