Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review
First author：Li, Hao
Corresponding author：Cao, Yong Zhao, Jizong
essential_information
2017-02-01
Published articles
Journal：Childs Nerv Syst
Publication type: Original Paper
IF(IF): 1.327
PMID: 27787647 Link To Pubmed Full text Download
Background And Purpose
Method
From January 2005 to June 2016, we retrospectively reviewed seven pediatric intracranial CCMs in terms of their clinical data, preoperative MRI features, and prognosis. Moreover, a critical review of the English language literature was also conducted.
Conclusion
Pediatric intracranial CCMs have a tendency to recur. There is a significant relationship between MIB-1 labeling index and recurrence. Gross total resection is recommended; if not available, adjuvant radiotherapy should be used to reduce the recurrent rate. In addition, postoperative MRI follow-up should be monitored at an interval time after resection.
Main results
The patients consisted of two males and five females with a median age of 10.5 years (range 6-15 years) at initial surgery. Petroclival and cerebellopontine angle area was the most common location site (5/7). Accordingly, the most common initial manifestation was hearing loss (3/7), and the mean interval from onset of symptoms to admission was 6.8 months (1.5-24 months). Gross total resection was achieved in five patients. Of the six tumors with immunohistochemical records, MIB-1 labeling index varied from 3 to 20 % (mean 8.1 %). During the follow-up period (mean 76.9 months, range 16-180 months), four patients had experienced tumor recurrences and three patients died due to recurrences.