国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

第一作者：Tian Yonglu

通讯作者：Zhang Chen

Short-Term Memory Prefrontal Cortex

基本信息

  • 负责人：Tian Yonglu
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190612
  • 发表时间：2018-02-13

2018-02-13

已发表文章

发表杂志：Cell Reports

发表类型: Article

影响因子(IF): 9.423

PMID: 29444427 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Here, we performed two-photon imaging on behaving mice to monitor the activity of neuronal microcircuitry. We discovered a neuronal subpopulation in the medial prefrontal cortex (mPFC) that exhibited emergent properties in a context-dependent manner underlying a STM-like behavior paradigm. These neuronal subpopulations exclusively comprise excitatory neurons and mainly represent a group of neurons with stronger functional connections. Microcircuitry plasticity was maintained for minutes and was absent in an animal model of Alzheimer’s disease (AD).

结论

Thus, these results point to a functional coding mechanism that relies on the emergent behavior of a functionally defined neuronal assembly to encode STM.

主要结果