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An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex
First author：Tian Yonglu
Corresponding author：Zhang Chen
essential_information
- Person in charge：Tian Yonglu
- Data Sources： OTHERS
- Number of papers：OTHERS20190612
- Published time：2018-02-13
2018-02-13
Published articles
Journal：Cell Reports
Publication type: Article
IF(IF): 9.423
PMID: 29444427 Link To Pubmed Full text Download
Background And Purpose
Method
Here, we performed two-photon imaging on behaving mice to monitor the activity of neuronal microcircuitry. We discovered a neuronal subpopulation in the medial prefrontal cortex (mPFC) that exhibited emergent properties in a context-dependent manner underlying a STM-like behavior paradigm. These neuronal subpopulations exclusively comprise excitatory neurons and mainly represent a group of neurons with stronger functional connections. Microcircuitry plasticity was maintained for minutes and was absent in an animal model of Alzheimer’s disease (AD).
Conclusion
Thus, these results point to a functional coding mechanism that relies on the emergent behavior of a functionally defined neuronal assembly to encode STM.