Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma
First author：Li Guanzhang,Li Yiming
Corresponding author：Jiang Tao,Zhang Wei
essential_information
- Person in charge：Li Guanzhang,Li Yiming
- Data Sources： OTHERS
- Number of papers：OTHERS20190619
- Published time：2018-12-11
2018-12-11
Published articles
Journal：Cell Death & Disease
Publication type: Article
IF(IF): 8.469
PMID: 30538217 Link To Pubmed Full text Download
Background And Purpose
Method
Aldefluor, flow cytometry sorting and qRT-PCR were performed to verify the role of ALDH1A3 in ALDH activity maintenance. Transwell, immunofluorescence, glycolytic assays, and orthotopic xenograft models were used to explore ALDH1A3 bio-functions in GBM. LASSO-COX, COX survival analysis and Kaplan–Meier analysis were used to establish the prognostic evaluation system and predict postoperative chemotherapy sensitivity of GBMs.
Conclusion
In conclusion, ALDH1A3 was a major contributor to ALDH activity and a key driver in triggering mesenchymal transformation in GBM. ALDH1A3-based molecular classification scheme can help to improve guidance for prognosis forecasting and individualized treatment decision making for GBM patients.
Main results
Our integrated study found that (1) ALDH1A3 associates with mesenchymal differentiation of GBM in Eastern and Western world patients. (2) ALDH1A3 plays a critical role in ALDH activity maintenance. (3) ALDH1A3 is an activator of mesenchymal transformation in GBM. (4) ALDH1A3-derived PMT markers’ molecular signature can predict 1-, 2-, and 3-year survival rates of GBMs precisely.