Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis
First author：Wang Youxin,Zhou Bin
Corresponding author：Wu Shouling,Zhao Xingquan,Zhou Yong
essential_information
- Person in charge：Wang Youxin,Zhou Bin
- Data Sources： OTHERS
- Number of papers：OTHERS20190627
- Published time：2018-04-01
2018-04-01
Published articles
Journal：J Cell Mol Med
Publication type: Original Article
IF(IF): 5.31
PMID: 29424477 Link To Pubmed Full text Download
Background And Purpose
Method
A cross-sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS). Serum Lp-PLA2 mass was determined by enzyme-linked immunosorbent assay (ELISA). All participants underwent transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS).
Conclusion
Lp-PLA2 mass is positively correlated with subclinical atherosclerosis determined by ACAS, ICAS and ECAS in North Chinese, particularly in male and older participants, suggesting that serum Lp-PLA2 mass might be potential biomarker for the detection of ACAS in the adults.
Main results
The median serum Lp-PLA2 mass of the participants was 140.74 ng/mL (interquartile range: 131.79-158.07 ng/mL). The adjusted odds ratio (OR) when comparing the 4th quartile to the 1st quartile of Lp-PLA2 was 1.98 (95% confidence interval (CI): 1.42-2.78), 1.79 (95% CI: 1.08-2.94) and 1.87 (95% CI: 1.28-2.73) for the occurrence of ACAS, asymptomatic ECAS and asymptomatic ICAS, respectively, after controlling for vascular risk factors. These independently significant associations remained statistically significant in the male or elderly subgroups, but not in females or middle-aged participants.