国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Risk factors of pure leukoaraiosis and the association with preclinical carotid atherosclerosis
第一作者：Yu Xueying
通讯作者：Wang Guihong ,Xu Jun
基本信息
- 负责人：Yu Xueying
- 数据来源： OTHERS
- 论文编号：OTHERS20190634
- 发表时间：2018-08-01
2018-08-01
已发表文章
主要研究背景及目的
方法
Data from 384 subjects with leukoaraiosis and 379 controls with normal cerebral parenchyma were collected at the Beijing Tiantan Hospital from 1 January, 2009 to 31 December, 2015. Entry criteria: 1) age over 40 years; 2) not taking lipid lowering drugs and vitamin B; 3) normal cerebral parenchyma or leukoaraiosis on brain MRI scan; 4) intra- and extra-cranial large artery stenosis less than 50%.
结论
Only age and hypertension are independently related to pure leukoaraiosis, and there is no association between pure leukoaraiosis and preclinical carotid atherosclerosis.
主要结果
Age and hypertension, but not serum homocysteine, vitamin B12, folic acid, or serum lipid profile, were independently associated with leukoaraiosis. Furthermore, there was no significant association between pure leukoaraiosis and preclinical carotid atherosclerosis after adjusting for age.