Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Risk factors of pure leukoaraiosis and the association with preclinical carotid atherosclerosis
First author：Yu Xueying
Corresponding author：Wang Guihong ,Xu Jun
essential_information
- Person in charge：Yu Xueying
- Data Sources： OTHERS
- Number of papers：OTHERS20190634
- Published time：2018-08-01
2018-08-01
Published articles
Journal：Atherosclerosis
Publication type: Research Article
IF(IF): 5.162
PMID: 30015295 Link To Pubmed Full text Download
Background And Purpose
Method
Data from 384 subjects with leukoaraiosis and 379 controls with normal cerebral parenchyma were collected at the Beijing Tiantan Hospital from 1 January, 2009 to 31 December, 2015. Entry criteria: 1) age over 40 years; 2) not taking lipid lowering drugs and vitamin B; 3) normal cerebral parenchyma or leukoaraiosis on brain MRI scan; 4) intra- and extra-cranial large artery stenosis less than 50%.
Conclusion
Only age and hypertension are independently related to pure leukoaraiosis, and there is no association between pure leukoaraiosis and preclinical carotid atherosclerosis.
Main results
Age and hypertension, but not serum homocysteine, vitamin B12, folic acid, or serum lipid profile, were independently associated with leukoaraiosis. Furthermore, there was no significant association between pure leukoaraiosis and preclinical carotid atherosclerosis after adjusting for age.