国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Cognitive behavioral therapy for post-stroke depression: A meta-analysis
第一作者：Wang Shi-Bin
通讯作者：Xiang Yu-Tao
基本信息
- 负责人：Wang Shi-Bin
- 数据来源： PRIOD
- 论文编号：OTHERS20190639
- 发表时间：2018-08-01
2018-08-01
已发表文章
发表杂志：Journal of Affective Disorders
发表类型: Meta-analysis
影响因子(IF): 4.839
PMID: 29704854 Pubmed原文链接 全文下载
主要研究背景及目的
方法
Both English (PubMed, PsycINFO, Embase) and Chinese (WanFang Database, Chinese National Knowledge Infrastructure and SinoMed) databases were systematically searched. Weighted and standardized mean differences (WMDs/SMDs), and the risk ratio (RR) with their 95% confidence intervals (CIs) were calculated using the random effects model.
结论
Although this meta-analysis found positive effects of CBT on depressive symptoms in PSD, the evidence for CBT is still inconclusive due to the limitations of the included studies. Future high-quality RCTs are needed to confirm the benefits of CBT in PSD.
主要结果
Altogether 23 studies with 1,972 participants with PSD were included and analyzed. Of the 23 RCTs, 39.1% (9/23) were rated as high quality studies, while 60.9% (14/23) were rated as low quality. CBT showed positive effects on PSD compared to control groups (23 arms, SMD = −0.83, 95% CI: −1.05 to −0.60, P < 0.001). Both CBT alone (7 arms, SMD = −0.76, 95% CI: −1.22 to −0.29, P = 0.001) and CBT with antidepressants (14 arms, SMD = −0.95, 95% CI: −1.20 to −0.71, P < 0.00001) significantly improved depressive symptoms in PSD. CBT had significantly higher remission (6 arms, RR = 1.76, 95% CI: 1.37–2.25, P < 0.00001) and response rates (6 arms, RR = 1.41, 95% CI: 1.22–1.63, P < 0.00001), with improvement in anxiety, neurological functional deficits and activities of daily living. CBT effects were associated with sample size, mean age, proportion of male subjects, baseline depression score, mean CBT duration, mean number of CBT sessions, treatment duration in each session and study quality.