Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The role of the microRNA-146a/complement factor H/interleukin-1 beta-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy
First author：Li Tao-Ran
Corresponding author：Lv Rui-Juan
essential_information
- Person in charge：Li Tao-Ran
- Data Sources： OTHERS
- Number of papers：OTHERS20190641
- Published time：2018-02-18
2018-02-18
Published articles
Journal：Disease Models & Mechanisms
Publication type: Article
IF(IF): 5.758
PMID: 29590637 Link To Pubmed Full text Download
Background And Purpose
Method
We found that enhancive miR-146a could upregulate the expression of IL-1β and downregulate the expression of CFH, whereas reductive miR-146a could downregulate the expression of IL-1β and upregulate the expression of CFH, in hippocampi of chronic TLE rat models. Meanwhile, enhancive miR-146a could increase the abnormal wave forms in the chronic TLE rat models. Additionally, enhancive IL-1β could feedback downregulate the expression of CFH, upregulate the expression of miR-146a and increase the abnormal wave forms in chronic TLE rat models. After CFH gene knockdown in U251 cells, enhancive miR-146a did not upregulate the expression of IL-1β.
Conclusion
Therefore, modulation of the miR-146a–CFH–IL-1β loop circuit could be a novel therapeutic target for TLE.
Main results
In summary, this study shows that enhancive miR-146a can upregulate the inflammatory factor IL-1β in chronic TLE by downregulating CFH, and that upregulation of IL-1β plays an important feedback-regulating role in the expression of miR-146a and CFH, forming a miR-146a–CFH–IL-1β loop circuit that initiates a cascade of inflammation and then leads to the perpetuate inflammation in TLE.