国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis

第一作者：Zhang Jia, Liu Yanfang

通讯作者：Chen Shengyun,Zhao Xingquan

H-type Hypertension Asymptomatic Extracranial Arte

基本信息

2018-01-22

已发表文章

发表杂志：Sci Rep.

发表类型: Research Article

影响因子(IF): 4.011

PMID: 29358636 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We included 2330 participants in this study and classified them into four groups: the control group without hypertension or hyperhomocysteinemia, isolated hypertension group, isolated hyperhomocysteinemia group and H-type hypertension group. We measured the baseline plasma total homocysteine levels and assessed ECAS by carotid duplex sonography twice at baseline and during follow up. We used a Cox regression model to analyse the association between H-type hypertension and ECAS. At baseline, 608 subjects suffered from H-type hypertension.

结论

Our findings provide direct evidence for the importance of H-type hypertension in the occurrence of ECAS and as a potential therapeutic target for carotid atherosclerosis.

主要结果

Within two years of follow-up, asymptomatic ECAS occurred in 250 (10.73%) participants. After adjusting for relevant risk factors, we found H-type hypertension to be an independent risk factor for asymptomatic ECAS (relative risk (RR) 3.16, 95% confidence interval (95% CI) 2.00-5.00).