Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis
First author：Zhang Jia, Liu Yanfang
Corresponding author：Chen Shengyun,Zhao Xingquan
essential_information
- Person in charge：Zhang Jia, Liu Yanfang
- Data Sources： OTHERS
- Number of papers：OTHERS20190643
- Published time：2018-01-22
2018-01-22
Published articles
Journal：Sci Rep.
Publication type: Research Article
IF(IF): 4.011
PMID: 29358636 Link To Pubmed Full text Download
Background And Purpose
Method
We included 2330 participants in this study and classified them into four groups: the control group without hypertension or hyperhomocysteinemia, isolated hypertension group, isolated hyperhomocysteinemia group and H-type hypertension group. We measured the baseline plasma total homocysteine levels and assessed ECAS by carotid duplex sonography twice at baseline and during follow up. We used a Cox regression model to analyse the association between H-type hypertension and ECAS. At baseline, 608 subjects suffered from H-type hypertension.
Conclusion
Our findings provide direct evidence for the importance of H-type hypertension in the occurrence of ECAS and as a potential therapeutic target for carotid atherosclerosis.
Main results
Within two years of follow-up, asymptomatic ECAS occurred in 250 (10.73%) participants. After adjusting for relevant risk factors, we found H-type hypertension to be an independent risk factor for asymptomatic ECAS (relative risk (RR) 3.16, 95% confidence interval (95% CI) 2.00-5.00).