Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of estimated glomerular filtration rate and proteinuria with all-cause mortality in community-based population in China: A Result from Kailuan Study
First author：Wu Jianwei,Jia Jiaokun
Corresponding author：Guo Xiuhua,Wu Shouling,Zhao Xingquan
essential_information
- Person in charge：Wu Jianwei,Jia Jiaokun
- Data Sources： APAC
- Number of papers：OTHERS20190644
- Published time：2018-02-01
2018-02-01
Published articles
Journal：Sci. Rep.
Publication type: Research Article
IF(IF): 4.011
PMID: 29391563 Link To Pubmed Full text Download
Background And Purpose
Method
Data were analysed based on Cox proportional hazards models with adjustment for relevant confounders, and the results were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs). During eight years of follow-up, a total of 6024 participants died.
Conclusion
In conclusion, both severely decreased eGFR and proteinuria are independent predictors of all-cause mortality in the general northern Chinese population. A combination of severely decreased eGFR and proteinuria increases the risk of all-cause mortality, which is even over 5-fold higher in females.
Main results
The two indicators, eGFR < 45 ml/min/1.73 m2 and the presence of proteinuria, were independently associated with all-cause mortality. Compared with eGFR ≥45 ml/min/1.73 m2 with negative proteinuria, HRs of all-cause mortality were 1.26 (95% CI 1.10-1.44) for eGFR < 45 ml/min/1.73 m2 without proteinuria, 1.95 (1.78-2.14) for eGFR ≥45 ml/min/1.73 m2 with proteinuria, and 2.63 (2.14-3.23) for eGFR < 45 ml/min/1.73 m2 with proteinuria. The all-cause mortality risk of eGFR and/or proteinuria was much higher in females than in males (P for interaction < 0.01).