Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Parkinson disease with constipation: clinical features and relevant factors
First author：Yu Qiu-Jin
Corresponding author：Zhang Wei
essential_information
- Person in charge：Yu Qiu-Jin
- Data Sources： OTHERS
- Number of papers：OTHERS20190646
- Published time：2018-01-12
2018-01-12
Published articles
Journal：Sci Rep.
Publication type: Research Article
IF(IF): 4.011
PMID: 29330419 Link To Pubmed Full text Download
Background And Purpose
Method
PD patients were evaluated by diagnostic criteria of functional constipation in Rome III and divided into PD with constipation (PD-C) and PD with no constipation (PD-NC) groups. PD patients were assessed by rating scales of motor symptoms and other non-motor symptoms, activity of daily living and quality of life.
Conclusion
Binary Logistic regression analysis showed that the age, H-Y stage, depression, anxiety and autonomic dysfunction increased the risk of constipation in PD patients. Constipation exerted serious impact on the activity of daily living and quality of life in PD patients.
Main results
The frequency of constipation in PD patients was 61.4%, and 24.5% of PD patients had constipation before the onset of motor symptoms. PD-C group had older age and age of onset, longer disease duration, more advanced disease stage, and more severe motor symptoms and non-motor symptoms, including worse cognition and emotion, poorer sleep quality, severer autonomic symptoms, fatigue and apathy.