国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

The association of regional white matter lesions with cognition in a community-based cohort of older individuals

第一作者：Jiang Jiyang

通讯作者：Jiang Jiyang

Cognitive performance Community-dwelling older ind

基本信息

  • 负责人：Jiang Jiyang
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190651
  • 发表时间：2018-03-29

2018-03-29

已发表文章

发表杂志：Neuroimage Clin

发表类型: Research Article

影响因子(IF): 3.943

PMID: 30034997 Pubmed原文链接 全文下载

主要研究背景及目的

方法

In the current study, we undertook a region of interest (ROI) LSM study to examine the relationship between regional WML on strategic WM tracts and cognitive performance in a large community-based cohort of older individuals (N = 461; 70-90 years). WML were extracted using a publicly available pipeline, UBO Detector (https://cheba.unsw.edu.au/group/neuroimaging-pipeline). Mapping of WML to the Johns Hopkins University WM atlas was undertaken using an automated TOolbox for Probabilistic MApping of Lesions (TOPMAL), which we introduce here, and is implemented in UBO Detector. The results show that different patterns of brain structural volumes in the ageing brain were associated with different cognitive domains. Regional WML were associated with processing speed, executive function, and global cognition, independent of total GM, WM and WML volumes. Moreover, regional WML explained more variance in executive function, compared to total GM, WM and WML volumes.

结论

The current study highlights the importance of studying regional WML in age-related cognitive decline.

主要结果