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Attenuation of EGFL7 Expression Inhibits Growth Hormone-Producing Pituitary Adenomas Growth and Invasion

First author：Liu Qian, Wang Jianpeng

Corresponding author：Zhang Yazhuo

EGFL7 Notch signaling pathway growth hormone–produ

essential_information

2018-04-02

Published articles

Journal：Hum Gene Ther

Publication type: Research Article

IF(IF): 5.695

PMID: 29466872 Link To Pubmed Full text Download

Background And Purpose

Method

This study reports that EGFL7 and Notch2 (positive correlation with EGFL7) are overexpressed in invasive GHPA. A long-rank test (Kaplan-Meier method) shows that invasive GHPAs with EGFL7 strong expression results in reduced recurrence-free survival. Multivariate Cox regression analysis reveals that weak EGFL7 expression is an independent prognostic factor for recurrence-free survival. In addition, knockdown of EGFL7 expression suppresses proliferation and invasion of GH3 and GT1-1 cells in vitro. Moreover, attenuation of EGFL7 inhibits human GHPA growth in vivo.

Conclusion

The data suggest that as a Notch agonist, EGFL7 may potentially be an appropriate novel molecular target for future development of GHPA medical therapy.

Main results