Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke-——CHANCE substudy

First author：Xianwei Wang

Corresponding author：Yongjun Wang,Yilong Wang

essential_information

  • Person in charge：Xianwei Wang
  • Data Sources： CHANCE
  • Number of papers：CHANCE20150112
  • Published time：2015-08-18

2015-08-18

Published articles

Journal：Neurology

Publication type: Original Contributions

IF(IF): 9.91

PMID: 26283758 Link To Pubmed Full text Download

Background And Purpose

We compared the effect of clopidogrel plus aspirin vs aspirin alone on functional outcome and quality of life in the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial of aspirin-clopidogrel vs aspirin alone after acute minor stroke or TIA.

Method

Participants were assessed at 90 days for functional outcome using the modified Rankin Scale (mRS) and quality of life using the EuroQol-5 Dimension (EQ-5D). Poor functional outcome was defined as mRS score of 2–6 at 90 days and poor quality of life as EQ-5D index score of 0.5 or less.

Conclusion

Main results