Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The Correlations between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer's Disease
First author：Qiu Wen-Ying,Yang Qian,Zhang Wanying
Corresponding author：HuangYue, Ma Chao
essential_information
- Person in charge：Qiu Wen-Ying,Yang Qian,Zhang Wanying
- Data Sources： OTHERS
- Number of papers：OTHERS20190667
- Published time：2018-03-14
2018-03-14
Published articles
Journal：Curr Alzheimer Res
Publication type: Article
IF(IF): 3.498
PMID: 29110614 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 52 human brains with antemortem cognitive status information [Everyday Cognition (ECog)] were collected through the willed donation program by CAMS/PUMC Human Brain Bank. Pathological changes were evaluated with the "ABC" score following the guidelines of NIA-AA. The clinicopathological relationship was analyzed with correlation analysis and general linear multivariate model.
Conclusion
In this study, we verified the correlation of postmortem C and B scores, but not the A score with cognition performance in a collection of samples from the Chinese human brain bank.
Main results
The general ABC score has a significant correlation with global ECog score (r=0.37, p=0.014) and most of ECog domains. The CERAD score of neuritic plaques (C score) has a significant correlation with global ECog score (r=0.40, p=0.007) and the majority of ECog domains, such as memory (r=0.50, p=0.001), language (r=0.45, p=0.002), visuospatial functions (r=0.31, p=0.040), planning (r=0.35, p=0.021) and organization (r=0.39, p=0.010). The Braak stage of neurofibrillary tangles (NFTs) (B score) has a moderate correlation with memory (r=0.32, p=0.035). The Thal phases of amyloid-β (Aβ) deposits (A score) present no significant correlation with any of ECog domains.