国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

SNF5 as a prognostic factor in skull base chordoma

第一作者：Li Mingxuan, Zhai Yixuan, Yixuan

通讯作者：Zhang Yazhuo, Yazhuo

基本信息

2018-03-01

已发表文章

发表杂志：J Neurooncol

发表类型: Clinical Study

影响因子(IF): 3.129

PMID: 29222701 Pubmed原文链接

主要研究背景及目的

方法

48 patients diagnosed with skull base chordoma were enrolled in this study. Tissue microarray and immunohistochemistry were performed to evaluate the expression of SNF5 in skull base chordoma. Kaplan-Meier survival analysis was used to assess survival. Multivariable Cox regression analysis was used to identify risk factors affecting patient survival. The H-scores for cytoplasmic SNF5 ranged from 124.47 to 254.52. Low expression of SNF5 was correlated with shorter overall survival (OS) (p = 0.021). Patients with age > 55 years old had shorter progression free survival (PFS) and OS times than patients whose age ≤ 55 years old (p = 0.005 and 0.003, respectively). The gross total resection group showed longer PFS than the non-gross total resection group (p = 0.024). Females showed shorter PFS times than males (p = 0.033).

结论

Our study indicate that low expression of SNF5 is associated with poor prognosis in skull base chordoma.

主要结果

Multivariable Cox regression analysis showed that age, extent of resection and sex were independent prognostic factors for PFS (p = 0.010, 0.013 and 0.042, respectively). Age was an independent prognostic factor for OS (p = 0.010).