Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
SNF5 as a prognostic factor in skull base chordoma
First author：Li Mingxuan, Zhai Yixuan, Yixuan
Corresponding author：Zhang Yazhuo, Yazhuo
essential_information
- Person in charge：Li Mingxuan, Zhai Yixuan, Yixuan
- Data Sources： OTHERS
- Number of papers：OTHERS20190675
- Published time：2018-03-01
2018-03-01
Published articles
Background And Purpose
Method
48 patients diagnosed with skull base chordoma were enrolled in this study. Tissue microarray and immunohistochemistry were performed to evaluate the expression of SNF5 in skull base chordoma. Kaplan-Meier survival analysis was used to assess survival. Multivariable Cox regression analysis was used to identify risk factors affecting patient survival. The H-scores for cytoplasmic SNF5 ranged from 124.47 to 254.52. Low expression of SNF5 was correlated with shorter overall survival (OS) (p = 0.021). Patients with age > 55 years old had shorter progression free survival (PFS) and OS times than patients whose age ≤ 55 years old (p = 0.005 and 0.003, respectively). The gross total resection group showed longer PFS than the non-gross total resection group (p = 0.024). Females showed shorter PFS times than males (p = 0.033).
Conclusion
Our study indicate that low expression of SNF5 is associated with poor prognosis in skull base chordoma.
Main results
Multivariable Cox regression analysis showed that age, extent of resection and sex were independent prognostic factors for PFS (p = 0.010, 0.013 and 0.042, respectively). Age was an independent prognostic factor for OS (p = 0.010).