Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
First author：Liu Yaou
Corresponding author：Li Kuncheng,Shu Ni
essential_information
2018-04-10
Published articles
Journal：Front Hum Neurosci
Publication type: Original Research
IF(IF): 3.169
PMID: 29692717 Link To Pubmed Full text Download
Background And Purpose
Method
Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant.
Conclusion
Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability.
Main results
For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS.