Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis
First author：Wang Wen,Li Hao, Hao
Corresponding author：Cao Yong,Zhao Jizong, Jizong
essential_information
- Person in charge：Wang Wen,Li Hao, Hao
- Data Sources： OTHERS
- Number of papers：OTHERS20190698
- Published time：2018-04-01
2018-04-01
Published articles
Journal：Neurosurg Rev
Publication type: Article
IF(IF): 3.042
PMID: 29032423 Link To Pubmed Full text Download
Background And Purpose
Method
We collected 12 IAs samples and 12 control arteries from the Beijing Tiantan Hospital and performed microarray analysis. In addition, we utilized the microarray datasets of IAs and AAAs from the Gene Expression Omnibus (GEO), in combination with our microarray results, to generate messenger RNA expression profiles for both AAAs and IAs in our study. Functional exploration and protein-protein interaction (PPI) analysis were performed.
Conclusion
Our study will gain new insight into the molecular mechanisms for the pathogenesis of both types of aneurysms and provide new therapeutic targets for the patients harboring AAAs and IAs.
Main results
A total of 727 common genes were differentially expressed (404 was upregulated; 323 was downregulated) for both AAAs and IAs. The GO and pathway analyses showed that the common dysregulated genes were mainly enriched in vascular smooth muscle contraction, muscle contraction, immune response, defense response, cell activation, IL-6 signaling and chemokine signaling pathways, etc. The further protein-protein analysis identified 35 hub nodes, including TNF, IL6, MAPK13, and CCL5. These hub node genes were enriched in inflammatory response, positive regulation of IL-6 production, chemokine signaling pathway, and T/B cell receptor signaling pathway.