Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
A Comparative Proteomics Analysis of Five Body Fluids: Plasma, Urine, Cerebrospinal Fluid, Amniotic Fluid, and Saliva
First author：Zhao Mindi, Mindi
Corresponding author：Sun Wei, Wei
essential_information
- Person in charge：Zhao Mindi, Mindi
- Data Sources： OTHERS
- Number of papers：OTHERS20190702
- Published time：2018-11-01
2018-11-01
Published articles
Journal：Proteomics Clin Appl
Publication type: Research Article
IF(IF): 2.324
PMID: 29781159 Link To Pubmed Full text Download
Background And Purpose
Method
To determine differences in the protein components and functional features of body fluids, a proteomic comparison of five body fluids (plasma, urine, cerebrospinal fluid, saliva, and amniotic fluid) was conducted by high-resolution mass spectrometry.
Conclusion
The quantitative comparative functional analysis indicated that body fluids might reflect the diverse functions of the whole body rather than the characteristics of their adjacent tissues. The above data might indicate the potential application of body fluids for biomarker discovery.
Main results
A total of 4717 nonredundant proteins were identified, and the concentrations of 3433 proteins were estimated by an intensity-based algorithm quantitation method. Among them, 564 proteins were shared among the five body fluids, with common functions in the coagulation/prothrombin system and inflammatory response. A total of 36.7% of the proteins were detected in only one body fluid and were closely related to their adjacent tissues by function. The functional analysis of the remaining 2986 proteins showed that similar functions might be shared among different body fluids, which highlighted intimate connection in the body.