Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study
First author：Yu, Shu-Yang
Corresponding author：Zhang, Wei
essential_information
- Person in charge：Yu, Shu-Yang
- Data Sources： OTHERS
- Number of papers：OTHERS20190705
- Published time：2018-01-17
2018-01-17
Published articles
Journal：BMC Neurol
Publication type: Research Article
IF(IF): 2.474
PMID: 29343241 Link To Pubmed Full text Download
Background And Purpose
Method
PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group. Motor symptoms (MS) and non-motor symptoms (NMS) were evaluated, and the levels of iron and related proteins in serum and cerebrospinal fluid (CSF) were detected for PD patients. Data comparison between the two groups and correlation analyses were performed.
Conclusion
PD patients with hyper echogenicity in SN are older, at more advanced disease stage, have severer motor symptoms, and non-motor symptoms of cognitive impairment and autonomic dysfunction. Hyper echogenicity of SN in PD patients is related to dysfunction of iron metabolism, involving increased iron transport from peripheral system to central nervous system, reduction of intracellular iron release and excessive iron deposition in brain.
Main results
PDSN+ group was significantly older, and had significantly older age of onset, more advanced Hohen-Yahr stage, higher SCOPA-AUT score and lower MoCA score than PDSN- group (P < 0.05). Compared with PDSN- group, the levels of transferrin and light-ferritin in serum and iron level in CSF were significantly elevated (P < 0.05), but ferroportin level in CSF was significantly decreased in PDSN+ group (P < 0.05).