国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus.
第一作者：Li, Qian
2018-03-01
已发表文章
主要研究背景及目的
方法
The present study used an experimental mouse model of autoimmune encephalomyelitis to verify the neuroprotective effects of catalpol. Significant improvements in the clinical scores were observed in catalpol‑treated mice. Furthermore, catalpol increased TH expression and increased noradrenaline levels in the spinal cord
结论
These results suggested that drugs targeting LC survival and function, including catalpol, may be able to benefit patients with MS.
主要结果
Furthermore, catalpol increased TH expression and increased noradrenaline levels in the spinal cord.In primary cultures, catalpol exerted a neuroprotective effect in rat LC neurons by increasing the noradrenaline output.