Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus.
First author：Li, Qian
Corresponding author：Guo, An-Chen Fan, Yong-Ping
essential_information
2018-03-01
Published articles
Journal：Mol Med Rep
Publication type: Article
IF(IF): 2.952
PMID: 29328415 Link To Pubmed Full text Download
Background And Purpose
Method
The present study used an experimental mouse model of autoimmune encephalomyelitis to verify the neuroprotective effects of catalpol. Significant improvements in the clinical scores were observed in catalpol‑treated mice. Furthermore, catalpol increased TH expression and increased noradrenaline levels in the spinal cord
Conclusion
These results suggested that drugs targeting LC survival and function, including catalpol, may be able to benefit patients with MS.
Main results
Furthermore, catalpol increased TH expression and increased noradrenaline levels in the spinal cord.In primary cultures, catalpol exerted a neuroprotective effect in rat LC neurons by increasing the noradrenaline output.