Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Analysis of Survival Prognosis for Children with Symptomatic Optic Pathway Gliomas Who Received Surgery
First author：Liu, Yuhan
Corresponding author：Tian, Yongji
essential_information
- Person in charge：Liu, Yuhan
- Data Sources： OTHERS
- Number of papers：OTHERS20190738
- Published time：2018-01-01
2018-01-01
Published articles
Journal：World Neurosurgery
Publication type: Article
IF(IF): 2.104
PMID: 28986229 Link To Pubmed Full text Download
Background And Purpose
Method
One-hundred twenty-five children diagnosed with OPGs underwent surgery in the Department of Neurosurgery, Beijing Tiantan Hospital from 2003-2016. In this retrospective study, their demographics, clinical characteristics, treatments, and survival outcomes were investigated and summarized.
Conclusion
Surgery is safe and feasible for children with large volumes of OPGs and symptoms of functional impairment and obstructive hydrocephalus. Furthermore, adjuvant RT after surgery may significantly improve OS and PFS. The pathologic grade is an independent prognostic factor for OS, and the age at diagnosis is an independent prognostic factor for PFS.
Main results
Among the 125 patients, the 5-year overall survival (OS) rate and progression-free survival (PFS) rate were 84.1% and 70.6%, respectively. In the univariate analysis, patients who received postoperative radiotherapy (RT) after surgery had significantly better 5-year OS and PFS rates than patients who did not receive RT (P < 0.001 for both comparisons), patients who were 3 years old had better PFS rates than younger patients (P < 0.001), and patients with endocrinology symptoms had significantly worse PFS rates than patients with other symptoms (P = 0.049). In the multiple regression analysis, postoperative treatment with RT and tumors with a lower pathologic grade were better predictors of OS. An age older than 3 years and postoperative treatment with RT were better predictors of PFS.