Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis
First author：Wang Jianpeng,Wang Dong, Dong
Corresponding author：Li, Chuzhong
essential_information
- Person in charge：Wang Jianpeng,Wang Dong, Dong
- Data Sources： OTHERS
- Number of papers：OTHERS20190744
- Published time：2018-09-01
2018-09-01
Published articles
Journal：World Neurosurg
Publication type: Original Article
IF(IF): 2.104
PMID: 29909209 Link To Pubmed Full text Download
Background And Purpose
Method
We detected and summarized the circRNA expression pattern in 75 NFA tissues from 10 noninvasive cases and 65 invasive cases and 9 pairs of NFA tumor tissues from 9 recurrent cases by circRNA microarrays. Accordingly, functional enrichment analysis and pathway analysis were performed and the circRNA-microRNA (miRNA) network was generated by bioinformatic analysis tools. Five new invasive NFA samples and 5 noninvasive NFA samples were collected to measure the microarray results.
Conclusion
This is the first study to conduct and comprehensively analyze the circRNA expression profile in invasive and recurrent NFA. Our finding will provide evidence for the significance of circRNAs in NFA diagnosis, prognosis, and clinical treatment.
Main results
A total of 570 dysregulated circRNAs (invasive tumor vs. noninvasive tumor) and 10 upregulated circRNAs (recurrent tumor tissue vs. first surgery tumor tissue) were identified based on the situation (fold change >2; P < 0.05). The parental genes of the dysregulated circRNAs in the comparison between invasion tumor and noninvasion tumor were found to be enriched in some cell adhesion signaling pathways such as Focal adhesion, Hippo signaling pathway, PI3K-Akt signaling pathway, and Adherens junction. The circRNA-miRNA network showed that the dysregulated circRNA may function as miRNA sponges.