国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

World Health Organization Grade III (Nonanaplastic) Meningioma: Experience in a Series of 23 Cases

第一作者：Zhang Gui-Jun, Zhang Guo-Bin, Zhang Yun-Sheng,Li Huan, Huan

通讯作者：Li Da, Wu Zhen, Zhang Jun-Ting, Jun-Ting

Papillary meningioma Stereotactic radiosurgery Rh

基本信息

2018-04-01

已发表文章

发表杂志：World Neurosurg

发表类型: Original Article

影响因子(IF): 2.104

PMID: 29382616 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Clinical data from 23 cases of PM and RM between January 2011 and December 2015 were retrospectively reviewed.

结论

We recommended adjuvant radiation regardless of the extent of resection. Individuals with PM or RM were at increased risk of recurrence and death; appropriate treatment for these patients should be further studied, and close follow-up is needed.

主要结果

The median follow-up was 38.0 months for World Health Organization grade III meningiomas. The mean progression-free survival (PFS) was 37.6 months, with 1-year, 3-year, and 5-year PFS of 78.3%, 50.8%, and 43.6%, respectively. The mean overall survival (OS) was 48.8 months, with 1-year, 3-year, and 5-year OS of 95.7%, 82.6%, and 44.0%, respectively. Univariate analysis showed that a ki-67 proliferation index >20% (hazard ratio [HR], 4.190; 95% confidence interval [CI], 1.033-17.001; P = 0.045) and PM (HR, 3.375; 95% CI, 0.998-11.408; P = 0.005) were related to worse PFS. Patients administered postoperative radiotherapy (PRT) after surgery had longer OS than did patients who did not receive PRT (median, 60.7 vs. 35.1 months; P = 0.029). Multivariate analysis showed that PRT was an independent factor for PFS (HR, 0.147; 95% CI, 0.033-0.657; P = 0.012) and OS (HR, 0.130; 95% CI, 0.025-0.691; P = 0.017) and that RM was an independent factor for PFS (HR, 7.312; 95% CI, 1.587-33.688; P = 0.011) and OS (HR, 6.447; 95% CI, 1.310-31.740; P = 0.022).