Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical characteristics associated with the intracranial dissemination of gliomas
First author：Cai Xu,Qin Jun-Jie, Jun-Jie
Corresponding author：Xie Jian, Jian
essential_information
- Person in charge：Cai Xu,Qin Jun-Jie, Jun-Jie
- Data Sources： OTHERS
- Number of papers：OTHERS20190756
- Published time：2018-03-01
2018-03-01
Published articles
Journal：Clin Neurol Neurosurg
Publication type: Research Article
IF(IF): 1.672
PMID: 29427894 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 629 patients with gliomas received tumor resection by the same surgeon from August 2010 to September 2015 were included in this study. The authors performed a retrospective review of the patients and the information regarding clinical features, histopathological results, molecular pathologic results and clinical outcomes was collected and analyzed.
Conclusion
In our study, older age (>40 years), high pathological grade, invasion of the corpus callosum and high levels of Ki-67 expression were risk factors associated with the intracranial dissemination of gliomas.
Main results
In this retrospective study, we found that the intracranial dissemination phenomenon occurred in 53 patients (8.43%). We analyzed the clinical characteristics of patients and found that the age at diagnosis (P = 0.011), WHO grade of the tumor (P < 0.001), and involvement of the corpus callosum (P = 0.010) were associated with the occurrence of dissemination. The higher grade of the tumor, the more prone to disseminate. Deletion of 1p/19q had no significant correlation with the intracranial dissemination. MMP9, Ki-67, and EGFR were highly expressed in tumor cells that caused dissemination, and the level of Ki-67 expression had significance in statistics (P < 0.01).