Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of Ring Finger Protein 213 Gene P.R4810k Polymorphism with Intracranial Major Artery Stenosis/Occlusion
First author：Zhang Qian, Qian
Corresponding author：Zhao Jizong, Jizong
essential_information
- Person in charge：Zhang Qian, Qian
- Data Sources： OTHERS
- Number of papers：OTHERS20190762
- Published time：2018-07-01
2018-07-01
Published articles
Journal：Journal of Stroke & Cerebrovascular Diseases
Publication type: Article
IF(IF): 2.136
PMID: 29482934 Link To Pubmed Full text Download
Background And Purpose
Method
We conducted a case-control study to estimate the association between the p.R4810K polymorphism and the risk of ICASO in a Chinese population. A total of 124 patients and 230 controls were enrolled. Moreover, a meta-analysis was performed to evaluate this association in the East Asian populations.
Conclusion
The p.R4810K polymorphism was associated with an increased risk of ICASO in the East Asian populations. Further studies on the function of the RNF213 protein and the clinical features of this subtype of ICASO are needed.
Main results
In our case-control study, the frequencies of the G/A genotype of p.R4810K were significantly higher in the ICASO patients than in the control group (4.03% versus .43%, P = .021, respectively). Moreover, in the meta-analysis, we assessed 7 case-control studies that included 1239 patients and 1377 controls. The pooled odds ratios (ORs) indicated significant association between the p.R4810K polymorphism and the ICASO risk in the dominant model (OR = 9.37, 95% confidence interval: 4.61-19.02, P = .000), the heterozygote comparison (OR = 8.97, 95% CI: 4.41-18.25, P = .000), and the allele comparison (OR = 9.50, 95% confidence interval: 4.71-19.19, P = .000) in the East Asian populations. Subgroup analysis based on ethnicity revealed that the risks in the Japanese and the Korean populations were higher than that in the Chinese population.