国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Anterior insular cortex plays a critical role in interoceptive attention

第一作者：Wang Xingchao,Wu Qiong

通讯作者：Wu Yanhong,Gao Zhixian,Fan Jin

基本信息

2019-02-17

已发表文章

发表杂志：Elife

发表类型: Research Article

影响因子(IF): 8.14

PMID: 30985277 Pubmed原文链接

主要研究背景及目的

方法

Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions.

结论

These results provide compelling evidence that the AIC plays a critical role in interoceptive attention.

主要结果

Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity.