国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Anterior insular cortex is a bottleneck of cognitive control

第一作者：Wu Tingting,Wang Xingchao,Wu Qiong

通讯作者：Wu Yanhong,Gao Zhixian,Fan Jin

基本信息

2019-07-15

已发表文章

发表杂志：Neuroimage

发表类型: Research Article

影响因子(IF): 6.556

PMID: 30798012 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study.

结论

These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.

主要结果

We found that the activation of the right anterior insular cortex (AIC) of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis.