Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Anterior insular cortex is a bottleneck of cognitive control
First author：Wu Tingting,Wang Xingchao,Wu Qiong
Corresponding author：Wu Yanhong,Gao Zhixian,Fan Jin
essential_information
- Person in charge：Wu Tingting,Wang Xingchao,Wu Qiong
- Data Sources： OTHERS
- Number of papers：OTHERS20190782
- Published time：2019-07-15
2019-07-15
Published articles
Journal：Neuroimage
Publication type: Research Article
IF(IF): 6.556
PMID: 30798012 Link To Pubmed Full text Download
Background And Purpose
Method
Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study.
Conclusion
These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.
Main results
We found that the activation of the right anterior insular cortex (AIC) of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis.