国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between non-high-density lipoprotein cholesterol levels and asymptomatic vulnerable carotid atherosclerotic plaques

第一作者：Wu J.,Zhang J.

通讯作者：Chen S.,Wu S.,Zhao X.

asymptomatic vulnerable carotid plaques atheroscle

基本信息

  • 负责人：Wu J.,Zhang J.
  • 数据来源： APAC
  • 论文编号：OTHERS20190795
  • 发表时间：2019-04-19

2019-04-19

已发表文章

发表杂志：Eur J Neurol

发表类型: Original Article

影响因子(IF): 6.089

PMID: 31002203 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We enrolled 2888 participants who underwent carotid atherosclerotic plaque detection and non-HDL-C measurement, with no history of taking lipid-lowering agents, from the Asymptomatic Polyvascular Abnormalities in Community study. We used multivariable logistic regression to estimate the association between non-HDL-C levels and the presence of asymptomatic vulnerable carotid atherosclerotic plaques.

结论

In our community-based observational and cross-sectional study, non-HDL-C level was a significant risk factor for the occurrence of asymptomatic vulnerable carotid plaques.

主要结果

In our study, 1505 subjects had asymptomatic vulnerable carotid atherosclerotic plaques and 1383 subjects had stable plaques. After adjustment for confounding factors, the odds ratios for vulnerable plaques of non-HDL-C levels in the middle and highest tertile groups were 1.02 (95% confidence interval, 0.84-1.23) and 1.50 (95% confidence interval, 1.23-1.82), respectively (P trend < 0.01).