Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between non-high-density lipoprotein cholesterol levels and asymptomatic vulnerable carotid atherosclerotic plaques
First author：Wu J.,Zhang J.
Corresponding author：Chen S.,Wu S.,Zhao X.
essential_information
- Person in charge：Wu J.,Zhang J.
- Data Sources： APAC
- Number of papers：OTHERS20190795
- Published time：2019-04-19
2019-04-19
Published articles
Journal：Eur J Neurol
Publication type: Original Article
IF(IF): 6.089
PMID: 31002203 Link To Pubmed Full text Download
Background And Purpose
Method
We enrolled 2888 participants who underwent carotid atherosclerotic plaque detection and non-HDL-C measurement, with no history of taking lipid-lowering agents, from the Asymptomatic Polyvascular Abnormalities in Community study. We used multivariable logistic regression to estimate the association between non-HDL-C levels and the presence of asymptomatic vulnerable carotid atherosclerotic plaques.
Conclusion
In our community-based observational and cross-sectional study, non-HDL-C level was a significant risk factor for the occurrence of asymptomatic vulnerable carotid plaques.
Main results
In our study, 1505 subjects had asymptomatic vulnerable carotid atherosclerotic plaques and 1383 subjects had stable plaques. After adjustment for confounding factors, the odds ratios for vulnerable plaques of non-HDL-C levels in the middle and highest tertile groups were 1.02 (95% confidence interval, 0.84-1.23) and 1.50 (95% confidence interval, 1.23-1.82), respectively (P trend < 0.01).